

If the player can play all five cards from their hand, they draw five more and continue playing. They must play either the next card in sequential order or a wild Skip-Bo card, using either cards in hand, the top card of their stock pile, or the top card of any of their four discard piles. Each turn the active player draws until they have five cards in hand, though there are cases of not drawing more cards to equal five cards, instead doing a draw of a certain number of cards.

The shared play area allows up to four build piles, which must be started using either a "1" card or a Skip-Bo, and each player also has up to four personal discard piles. Each player is dealt 30 cards (recommended 10-15 for faster gameplay) for their pile with only the top card visible, and a hand of five cards, and the remaining cards are placed face down to create a common draw pile. The player with the middle age goes first. The object of the game is to be the first player or team to play out their entire stock pile(s). Two to four people can play at a time as individuals, or, six or more players in teams (no more than three partnerships). The remainder of the fourth deck was discarded. In addition, the aces, twos and threes in the fourth deck were marked SKIP-BO. Before 1980, the commercial game consisted of four decks of regular playing cards with eight SKIP-BO cards replacing the standard two jokers in each deck. Alternatively, the 162 cards could be three regular decks of playing cards, including the jokers, with ace to queen corresponding to 1 to 12 and the kings and jokers corresponding to the SKIP-BO cards. The deck consists of 162 cards, twelve each of the numbers 1 through 12 and eighteen "SKIP-BO" wild cards which may be played as any number.
